肠道菌群失调与心血管疾病及其中医药调控研究进展

心血管疾病的发病率和死亡率正随着人口老龄化及城镇化的推进而呈持续升高之势，严重威胁人类的生命健康安全。心血管疾病的起病及病程进展受多种因素影响，肠道菌群失调作为其中之一吸引了众多目光。肠道菌群是存在于胃肠道内与人体互利共生的微生物群，越来越多的研究表明，肠道菌群与心血管疾病相互影响，二者互为因果，通过调节肠道菌群靶向干预心血管疾病可成为新的治疗思路。现代研究发现中药复方、中药单体及针灸可有效纠正肠道菌群紊乱，上调益生菌数量，恢复肠道屏障功能，减轻炎症反应。基于上述研究，该文总结了肠道菌群及其代谢产物与心血管疾病之间的相互作用，还对部分中医药调控肠道菌群，恢复肠道菌群动态平衡，从肠治心，干预心血管疾病的治疗作用进行了归纳，以期为心血管疾病的防治提供新的思路和可行性方案。

Research progress on the relationship between gut microbiota and cardiovascular diseases and the regulation of traditional Chinese medicine

With the development of population aging and urbanization, the morbidity and mortality of cardiovascular diseases are continuously increasing, posing a serious threat to human life, health and safety. The onset and course of cardiovascular diseases are affected by many factors, and the dysregulation of intestinal flora as one of them has attracted a lot of attention. Intestinal flora is a microflora that exists in the gastrointestinal tract and has a mutually-beneficial symbiosis with the human body. More and more studies have shown that the intestinal flora and cardiovascular diseases interact with each other, and the two are mutually causal, targeted intervention of cardiovascular diseases by regulating intestinal flora can become a new therapeutic idea. Modern studies have found that traditional Chinese medicine (TCM) compounds, TCM monomers and acupuncture can effectively correct the dysregulation of intestinal flora, up-regulate the number of probiotics, restore intestinal barrier function and reduce inflammation. Based on the above studies, this paper summarized the interaction between intestinal flora and its metabolites and cardiovascular diseases, and also summarized the therapeutic effects of some TCM in regulating intestinal flora, restoring the dynamic balance of intestinal flora, treating the heart with intestines and intervening in cardiovascular diseases, in order to provide new ideas and feasible schemes for the prevention and treatment of cardiovascular diseases.