GABA(A) alpha-1 subunit mediated desynchronization of elevated low frequency oscillations alleviates specific dysfunction in stroke – A case report |
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| Institution: | 1. Graduate Entry Medical School, University of Limerick, Limerick, Ireland;2. Centre for Interventions in Infection, Inflammation and Immunity, University of Limerick, Limerick, Ireland;3. Materials and Surface Science Institute, University of Limerick, Limerick, Ireland;4. Flinders University School of Medicine, Bedford Park, Adelaide, SA 5042, Australia;5. Applied Neurotherapeutics Research Group, Conway Institute, University College Dublin, Dublin 4, Ireland;1. Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada;2. Department of Surgery, University of Toronto, Toronto, Ontario, Canada;3. Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada;4. Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada;5. Neuroscience and Mental Health Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada;6. Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada;7. Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada |
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| Abstract: | ObjectiveThe paradoxical effects of the hypnotic imidazopyridine zolpidem, widely reported in persistent vegetative state, have been replicated recently in brain-injured and cognitively impaired patients. However, the neuronal mechanisms underlying these benefits are yet to be demonstrated. We implemented contemporary neuroimaging methods to investigate sensorimotor and cognitive improvements, observed in stroke patient JP following zolpidem administration.MethodsWe used Magnetic-Resonance-Imaging (MRI) and Magnetic-Resonance-Spectroscopy (MRS) to anatomically and chemically characterize stroke damage. Single-photon-emission-computed-tomography (SPECT) and magnetoencephalography (MEG) were used to identify changes in cerebrovascular perfusion and neuronal network activity in response to sub-sedative doses of zolpidem, zopiclone and placebo. Cognitive improvements were measured using the WAIS-III and auditory-verbal tasks.ResultsMRI and MRS revealed a lesion with complete loss of neuronal viability in the left temporal–parietal region; whilst SPECT indicated improved perfusion in the affected hemisphere following zolpidem. MEG demonstrated high-amplitude theta (4–10 Hz) and beta (15–30 Hz) oscillations within the peri-infarct region, which reduced in power coincident with zolpidem uptake and improvements in cognitive and motor function.ConclusionsIn JP, functional deficits and pathological oscillations appear coincidentally reduced following administration of low-dose zolpidem.SignificanceGABA(A) alpha-1 sensitive desynchronisation of pathological oscillations may represent a biomarker and potential therapeutic target in brain injury. |
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