Prevention of late complications with coverage agents in endoscopic resection of colorectal lesions: Current landscape in gastrointestinal endoscopy |
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Authors: | Vicente Lorenzo-Z iga Marco Bustamante-Bal n Vicente Pons-Beltr n |
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Affiliation: | Vicente Lorenzo-Zúñiga, Endoscopy Unit, Department of Gastroenterology, Hospital Universitari i Politècnic La Fe, Valencia 46026, SpainVicente Pons-Beltrán, Digestive Diseases Department, La Fe Polytechnic University Hospital, Valencia 46026, Spain |
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Abstract: | Endoscopic removal of large (≥ 20 mm) non-pedunculated colorectal lesions (LNPCLs) may result in major adverse events, such as delayed bleeding (DB) and delayed perforation (DP), despite closure of the mucosal defects with clips. Topical application of a coverage agent refers to the creation of a shield with a biocompatible medical device (tissue or hydrogel) with proven bioactive properties. Coverage of the eschar after endoscopic resection provides shielding protection to prevent delayed complications. The aim of the present review was to systematically collect and review the currently available literature regarding the prevention of DB and DP with coverage agents after endoscopic mucosal resection or endoscopic submucosal dissection of LNPCLs. |
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Keywords: | Large colorectal lesions Delayed bleeding Topical application Endoscopic mucosal resection Endoscopic submucosal dissection |
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