激素性和酒精性股骨头坏死局部BMP表达强度的比较研究

目的 比较研究激素性和酒精性股骨头坏死（ONFH）修复期股骨头内BMP表达强度并进行比较分析，进一步认识不同病因造成ONFH表现不同的分子生物学基础。方法 取13例股骨头坏死，其中7例激素性（男5例，女2例），6例酒精性（均为男性），另取新鲜股骨颈骨折3天内行全髋置换术的2例作为对照组。分别按照负重区软骨面、软骨下坏死中心、修复区和相对正常区取材，并制成石蜡切片，做BMP的免疫组织化学染色，分析其结果。结果 三组之间在积分光密度和数密度上，酒精组明显高于激素组和正常股骨颈骨折组（P〈0．05），而激素组在数值上小于正常组，但无显著性差异（P〉0．05）。结论 激素性ONFH和酒精性ONFH具有不同的BMP表达强度。且激素性ONFH的BMP表达强度弱于酒精性ONFH。

The comparison between the steroid- and alcohol - ONFH in the expression of BMPs

Objective To compare the expression of BMP in the femoral head of the steroid- and alcohol-ONFH in the stage of renovation and to take further to know the molecular biology of different appearance on ONFH.Methods The study included 13 femoral heads necrosis,which involves 7 caused by corticoid (5 men,2 women) and 6 by alcohol (6 men).The bone tissues from the appearance of bearing cartilage,center of necrosis under cartilage,renovating band and the normal head-neck area were made into general sections and their immunochemistric results about BMP was checked.Compare the results between the steroid- and alcohol-ONFH.Results The Total Optical Density(TOD) and the Quantitative Density(QD)of BMP in the alcohol-ONFH were higher than those in the steroid-ONFH and the fracture of femoral neck(P<0.05),and the amount of the steroid-ONFH was less than the fracture of femoral neck without statistical difference(P>0.05).Conclusions There is something different between the two groups in the expression of BMP.The expression of BMP in steroid-ONFH is less than that in alcohol-ONFH.