| 吡格列酮抑制人胶质瘤SNB19细胞生长及诱导其凋亡 |
| |
| 引用本文： | 刘大川,POSSINGER Kurt,ELSTNER Elena.吡格列酮抑制人胶质瘤SNB19细胞生长及诱导其凋亡[J].中国临床药理学杂志,2004,20(6):423-425. |
| |
| 作者姓名： | 刘大川 POSSINGER Kurt ELSTNER Elena |
| |
| 作者单位： | 1. 德国洪堡大学,医学院,癌症研究室,德国,柏林,10117;北京大学,医学部,病理生理学与生理学系,北京,100083
2. 德国洪堡大学,医学院,癌症研究室,德国,柏林,10117 |
| |
| 基金项目： | 德国柏林肿瘤研究基金资助项目(1166) |
| |
| 摘 要： | 目的 探讨吡格列酮(PGZ)对人神经胶质瘤细胞株SNB19增殖和凋亡的影响及其机制。方法 用MTT、流式细胞仪、Tunel和Western blot分析技术。结果 吡格列酮能够抑制SNB19细胞增殖和诱导其凋亡,同时伴有Bax表达的增高和pRb、Bcl-2表达的降低。结论 PGZ能够在体外抑制胶质瘤SNB19细胞的生长并诱导其凋亡,提示PGZ有可能成为一种新的治疗胶质瘤药物。
|
| 关 键 词： | 胶质瘤 吡格列酮 凋亡 增殖抑制 |
| 文章编号： | 1001-6821(2004)06-0423-03 |
Study on pioglitazone inhibits growth and induces apoptosis in human SNB19 glioma cells |
| |
| LIU Da-chuan,POSSINGER Kurt,ELSTNER Elena.Study on pioglitazone inhibits growth and induces apoptosis in human SNB19 glioma cells[J].The Chinese Journal of Clinical Pharmacology,2004,20(6):423-425. |
| |
| Authors: | LIU Da-chuan POSSINGER Kurt ELSTNER Elena |
| |
| Institution: | LIU Da-chuan1,2,POSSINGER Kurt1,ELSTNER Elena1 |
| |
| Abstract: | Objective To investigate the effect of pioglitazone(PGZ) on cell proliferationand apoptosis in human glioblastoma SNB19 cells and its possible mechanism.Methods MTT, flow cytometry, Tunel and Western blot were employed. Results PGZinhibited cell growth and induced apoptosis in SNB19 cells, which was associated withan increase of Bax and a reduction of pRb and Bcl-2 protein levels. Conclusion PGZinhibits cell growth and induces apoptosis in human glioblastoma SNB19 cells in vitro,indicating a therapeutic potential for PGZ in the treatment of glioma. |
| |
| Keywords: | glioblastoma pioglitazone apoptosis proliferation inhibition |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
