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Levels of BAFF in Serum in Primary Biliary Cirrhosis and Autoimmune Diabetes
Authors:I.R. Mackay  J. Groom  C.R. Mackay
Affiliation:1. Department of Biochemistry &2. Molecular Biology, Monash University, Clayton Campus, Victoria 3800, Australia;3. Department of Arthritis and Inflammation, The Garvan Institute of Medical Research, Darlinghurst NSW, Australia
Abstract:Levels of the B-cell activating cytokine BAFF are increased in serum in various autoimmune disease, and particularly Sjögren's syndrome in which there is evident B-lymphocyte proliferation. Studies in two autoimmune disease in which B-cell proliferation is less evident, primary biliary cirrhosis (PBC), and adult-onset Type 1 diabetes, showed serum levels of BAFF to be mostly in the normal range. A single raised level among eight sera tested in one patient studied with autoimmune hepatitis (AH) coincided with a relapse of the disease. Increased levels of BAFF in human sera, indexing a potent antigenic drive on B-cell production and survival in some autoimmune diseases, may mark only particular stages in the evolution of such diseases.
Keywords:Primary Biliary Cirrhosis  Diabetes  Lada  Baff  Autoimmunity
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