Bacterial extract (OM-89) specific and non specific immunomodulation in rheumatoid arthritis patients |
| |
| Authors: | Éric Toussirot Éric Robinet Philippe Saas Jacqueline Chabod Benoît Augé Gabriel Cozma |
| |
| Institution: | 1. CIC Biotherapy, St Jacques Hospital, 25000, Besan?on, France;2. IFR133, Besan?on, France;3. INSERM U645 UPRES EA2240, Plateforme de Biomonitoring, établissement Fran?ais du Sang, Bd Fleming, F-25020, Besan?on, France;4. University Hospital Jean Minjoz, Department of Rheumatology, Bd Fleming, F-25030, Besan?on cédex, France;5. OM PHARMA, 22 rue du Bois-du-Lan, 1217, Meyrin/Geneva, Switzerland |
| |
| Abstract: | The Escherichia Coli bacterial extract (OM-89) is used in the treatment of rheumatoid arthritis (RA). We evaluated the immunological changes induced by oral administration of OM-89 in 12 RA patients (polyclonal T cell reactivity to PHA, T cell precursor frequencies specific for OM-89 and Tetanus toxoid (TT), a control antigen and the release of Th1 (IFN-γ, TNF-α), Th2 (IL-4) and T regulatory 1 cell (Tr1) (IL-10) cytokines in the supernatants of PBMC cultures. Stimulation index in response to PHA decreased at month 3 as well as T cell precursor frequencies specific for TT with similar trends for OM-89-specific T cell precursor frequencies. OM-89 induced a strong production of IL-10, a significant decrease in IL-4 production while TNF-α and IFN-γ production tended to decrease during the study.Our results suggest that OM-89 has immunomodulatory properties by inducing changes in PBMC cytokines release suggestive of an induced Tr1 response to OM-89. |
| |
| Keywords: | Oral tolerance heat shock protein rheumatoid arthritis T regulatory cells Interleukin-10 |
|
|
