PDC expressing CD36, CD61 and IL-10 may contribute to propagation of immune tolerance |
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| Authors: | Marijo Parcina Martin Schiller Aline Gierschke Klaus Heeg |
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| Institution: | 1. Department of Medical Microbiology and Hygiene, Heidelberg University Hospital, Hygiene Institute, Heidelberg, Germany;2. Department of Internal Medicine, Heidelberg University Hospital, Heidelberg, Germany |
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| Abstract: | Human plasmacytoid dendritic cells (PDC) are blood dendritic cell antigen 2 (BDCA2) and blood dendritic cell antigen 4 (BDCA4) positive leukocytes that do not express common lineage markers. They have been described as proinflammatory innate immune cells and are the major source of αIFN in the human body. PDC-derived secretion of type I IFNs upon triggering of nucleic acid-sensing toll-like receptors (TLR) primes immune cells to rapidly respond to microbial stimuli and promotes a Th1 response. Here, we report that human PDC express CD36 and CD61 (β3 integrin), both involved in uptake of apoptotic cells and in induction of tolerance. Freshly isolated PDC and PDC within human blood leukocytes constitutively express IL-10. Thus, PDC may possess a so far neglected role in propagation of immune tolerance. |
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| Keywords: | PDC IL-10 tolerance CD36 CD61 |
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