| 前列腺癌MTS_1-P_(16)与突变P_(53)的表达研究 |
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| 引用本文： | 韩瑞发,吴国志,马腾骧.前列腺癌MTS_1-P_(16)与突变P_(53)的表达研究[J].现代泌尿外科杂志,1997(2). |
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| 作者姓名： | 韩瑞发 吴国志 马腾骧 |
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| 作者单位： | 天津市泌尿外科研究所天津医科大学第二医院，佳木斯中心医院，天津市泌尿外科研究所天津医科大学第二医院 天津300211，天津300211 |
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| 摘 要： | 应用单克隆抗体(MTS_1-P_(16(C-20))、PAb-DO-1-P_(53)免疫组化技术对38例高、中、低三种不同分化的前列腺癌MTS_1-P_(16)与突变P_(53)的表达率进行了比较研究。结果显示:在高、中、低三种不同分化的前列腺癌组织切片中MTS_1-P_(16)的阳性表达率为46.2％、21.4％和10％:突变P_(53)的阳性表达率为38.5％、71.4％和72.7％。MTS_1-P_(16)与突变P_(53)总的阳性表达率为23.6％和60.5％。结果提示:MTS_1-P_(16)的表达率随细胞分化恶化而丢失;突变P_(53)随细胞分化恶化表达率升高,MTS_1-P_(16)与P_(53)的丢失、突变与过度表达与肿瘤的发生及恶性生物学行为有关,同时测定MTS_1-P_(16)与突变P_(53)可作为评价前列腺癌预后新的生物学指标。
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| 关 键 词： | 前列腺癌 免疫组织化学 基因 |
Expression of MTS_1-P_(16) and Mutant P_(53) in Prostate Carcinoma |
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| Han Riufai Wu Guozhi,Ma Tengxiang.Expression of MTS_1-P_(16) and Mutant P_(53) in Prostate Carcinoma[J].Journal of MOdern Urology,1997(2). |
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| Authors: | Han Riufai Wu Guozhi Ma Tengxiang |
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| Abstract: | Immunohistochemical technique with monoclonal antibody (MTS1-P16. PAb-DO-1-P53) was used to study the expression of MTS1-P16 and mutant P53 tumor suppresser gene in paraffin embedded tissues of 38 cases of prostate cancer. The positive expression rates of MTS1-P16 were 46. 2% (6/13). 21. 4%(3/ 14) and 10%(1/11) in the well-differentiated, the moderate differentiated and the poorly differentiated prostate carcinoma respectively. The mutant P53 expression rates were 38. 7% (5/13), 71. 4% (10/14) and 72. 7% (8/11) in three differentiated prostate cancer respectively. Total positive expression rate of MTS1-P16 was 23. 6%. but the rate of P53 was 60. 5% (23/38) in all 38 cases of prostate carcinoma specimens. The results demonstrated that losses, mutant and over-expression of MTS1-P16 and P53 may be used as a new prognostic marker. |
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| Keywords: | Prostate cancer Immunohistochemistry Gene |
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