牛磺酸镁对自发性高血压大鼠血压的影响

目的研究新型配位化合物牛磺酸镁的抗高血压作用。方法静脉给药法研究牛磺酸镁对Ｗｉｓｔａｒ－Ｋｙｏｔｏ（ＷＫＹ）大鼠和自发性高血压大鼠（ＳＨＲ）的急性降压作用；口服给药法研究牛磺酸镁对ＳＨＲ的实验治疗学作用。结果牛磺酸镁（１０或２０ｍｇ／ｋｇ，ｉｖ）可迅速降低ＳＨＲ血压，并能减慢心率，但不影响ＷＫＹ大鼠血压。ＳＨＲ连续口服该配合物（２５ｍｇ／ｋｇ）１０天，能显著降低血压，但不影响心率。结论牛磺酸镁降压作用确切，有进一步开展临床研究的意义。

The Experimental Study of Antihypertensive Action of the Coordination Compound of Taurine and Magnesium in the Spontaneously Hypertensive Rat

Aim To study the anti-hypertensive action of a new coordination compound of taurine and magnesium(DAS). Methods Both the bolus intravenous and oral administration were used in the studies of the acute anti-hypertensive effects and the therapeutics effects of DAS in the spontaneously hypertensive rats(SHR). Results The artery blood pressures were rapidly reduced by DAS in 10 or 20 mg/kg iv and heart rate was decreased in SHR, but no obvious effect was seen in WKY. The oral administration of DAS(25 mg/kg) for 10 days can significantly decrease the artery blood pressure and heart rate was not changed. Conclusion Significant acute and chronic hypotensive effect has been shown by iv and p.o administration od DAS. A further clinic study is urgently necessary.