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| 非那雄胺对小鼠前列腺组织血管内皮细胞生长因子表达的影响 | |
| 引用本文： | 刘树硕,史时芳,谢家俊. 非那雄胺对小鼠前列腺组织血管内皮细胞生长因子表达的影响[J]. 现代泌尿外科杂志, 2002, 7(2): 92-94 |
| 作者姓名： | 刘树硕 史时芳 谢家俊 |
| 作者单位： | 1. 310006,浙江中医学院附属医院泌尿外科 2. 浙江大学医学院附属一院泌尿外科 3. 上海中药研究所 |
| 摘 要： | 目的 探讨非那雄胺对小鼠前列腺内血管内皮生长因子(VEGF)表达的影响。方法 采用流式细胞技术对服用不同剂量非那雄胺的小鼠前列腺增生组织标本作VEGF表达的测定。结果 非那雄胺明显抑制VEGF的表达,中剂量组和高剂量组与模型组之间比较有显著性差别(P<0.05和P<0.001)。结论 非那雄胺能显著抑制增生前列腺内VEGF的表达。 |
| 关 键 词： | 非那雄胺 前列腺增生症 血管内皮生长因子 |
| 修稿时间： | 2001-08-10 |
Effect of finasteride on VEGF expression in mouse prostatic tissue |
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| LIU Shushuo,SHI Shifang,XIE Jiajun,et al.. Effect of finasteride on VEGF expression in mouse prostatic tissue[J]. Journal of MOdern Urology, 2002, 7(2): 92-94 | |
| Authors: | LIU Shushuo SHI Shifang XIE Jiajun et al. |
| Affiliation: | LIU Shushuo,SHI Shifang,XIE Jiajun,et al. Department of Urology,the Affiliated Hospital of Zhejiang TCM Medical college,Hangzhou,310006. |
| Abstract: | Objective To investigate the effects of finasteride on VEGF expression in the mice prostate. Method 50 mice prostatic specimens of normal and BPH were evaluated for VEGF expression by flowcytomctry(FCM). Results Expression of VEGF was inhibited by finasteride. The difference between model group{ group B)and medium dose group(group D) .maximum dose group(group E)was significant (P<0.05 and P< 0. 001 ,respectively). Conclusion Finasteride is effective in inhibiting the expression of VEGF in the hyperplastic prostate Tissue of mouae. |
| Keywords: | Finastcride BPH VEGF |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |