Survivin在宫颈癌及癌前病变组织中的表达及意义

目的: 探讨Survivin原位杂交表达在宫颈癌及癌前病变诊断中的应用效果.方法: 选取45例宫颈癌患者病理组织为观察组,宫颈上皮内瘤变组织45例为对照1组,正常宫颈组织45例为对照2组.入试者均行Survivin原位杂交检测.结果: Survivin在对照2组、对照1组、观察组阳性率分别为2.2%、48.9%和84.4%,差异均有统计学意义(P<0.01).Survivin在宫颈癌Ⅰ期、Ⅱ期和Ⅲ期中的阳性率,在宫颈癌高分化组、中分化组及低分化组中的阳性率和在宫颈癌伴淋巴结转移组与不伴淋巴结转移组中阳性率差异均无统计学意义(P>0.05).结论: Suvrvini在宫颈癌及癌前病变的发生发展中发挥一定作用,可作为宫颈癌预后不良的标志之一.

The Survivin expression and its significance in cervical cancer and precancerous lesions

Objective： To investigate the application value of Survivin expression in the diagnosis of cervical cancer and precancerous lesions by in situ hybridization. Methods： The Survivin expressions in 45 tissue samples of cervical cancer（ observation group）,45 tissue samples of cervical intraepithelial neoplasia（ control group 1） and 45 normal cervical tissue samples（ control group 2） were detected by in situ hybridization. Results： The positive rates of Survivin expression in control group 2,control 1 group and observation group were 2. 2%,48. 9% and 84. 4%,respectively,the differences of which were statistically significant（ P〈0.01）. The differences of positive rate of Survivin expression in the patients with stage Ⅰ,Ⅱ and Ⅲ cervical cancer,high,moderate and low differentiation cervical cancer and cervical cancer complicated with and without lymph node metastasis were not statistically significant（P〉0. 05）.Conclusions： Survivin plays certain role in the occurrence and development of cervical cancer and precancerous lesions,which can be used as a sign of poor prognosis.