| 疏肝理脾片的药理及毒性研究 |
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| 引用本文： | 田文艺,兰芳.疏肝理脾片的药理及毒性研究[J].湖南中医药大学学报,1991,11(2):30-33. |
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| 作者姓名： | 田文艺 兰芳 |
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| 作者单位： | 湖南中医学院药理教研室 410007 |
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| 摘 要： | 将健康大白鼠随机分组并速成肝损伤模型。分别测定疏肝理脾片对肝损害大鼠SGPT、肝细胞色素P-450,及其免疫功能的影响。结果表明:疏肝理脾片能明显降低SGPT,提高肝细胞色素P-450的水平,对正常动物的T淋巴细胞转化率有明显的降低作用。本品的急性及长期毒性实验结果表明:毒性极低。
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| 关 键 词： | 疏肝理脾片 药理 毒性 |
RESEARCH ON PHARMACOLOGY & TOXICITY OF SHUGAN LIPI PIAN |
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| Tian Wenyi,et al Teaching-research Section of Pharmacology,Hunan college of Traditional Chinese Medicine.RESEARCH ON PHARMACOLOGY & TOXICITY OF SHUGAN LIPI PIAN[J].Journal of Traditional Chinese Medicine University of Hunan,1991,11(2):30-33. |
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| Authors: | Tian Wenyi Teaching-research Section of Pharmacology Hunan college of Traditional Chinese Medicine |
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| Abstract: | Healthy rabbits were divided into several groups at random and the rabbit model of impairment of liver was made. Effect of Shugan Lipi Pian (liver-soothing and spleen-regulating tablets) on the impaired rabbits SGPT, hepatic cytochrome P-450 and immunological function were observed. The result showed that Shugan Lipi Pian had function to lower SGPT markedly and to enhance the level of hepatic cytochrome P-450 in both of healthy and impaired rabbits, and to normal rabbits, and reduced the T-lymphocyte transformation rate markedly. The result of acute and long-term toxicity tests of this drug showed that it had little toxicity. |
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| Keywords: | @Shugan Lipi Pian radix bupleuri/pharmacology pericarpium citri reticulatae viride/phannacology radix bupleuri/toxicity pericarpium citri reticulatae viride/toxicity alanine transaminases/analysis liver disease/pathology |
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