| 2型糖尿病患者血清esRAGE水平及相关因素研究 |
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| 引用本文： | 樊华英,成兴波,范庆涛.2型糖尿病患者血清esRAGE水平及相关因素研究[J].苏州大学学报(自然科学版),2008,28(3). |
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| 作者姓名： | 樊华英 成兴波 范庆涛 |
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| 作者单位： | 苏州大学附属第一医院内分泌科,江苏苏州215006 |
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| 摘 要： | 目的 研究2型糖尿病(T2DM)患者血清内源性分泌型糖基化终产物受体(esRAGE)水平及其与相关因素的关系.方法 用酶联免疫法测定60例T2DM患者(其中30例并发颈动脉粥样硬化)和28名正常对照者血清esRAGE浓度,并检测其他临床指标.结果 T2DM并发颈动脉粥样硬化组血清esRAGE浓度较无颈动脉粥样硬化组及正常对照组显著降低,差异有高度统计学意义(P<0.01);T2DM无颈动脉粥样硬化组较正常对照组亦显著降低,差异有统计学意义(P<0.05).Pearson相关分析显示,esRAGE与年龄及代谢综合征的组成因素包括糖化血红蛋白、总胆固醇、低密度脂蛋白、收缩压、体质量指数成负相关(P<0.01).多元线性逐步回归分析显示,年龄、总胆固醇、糖化血红蛋白、体质量指数与esRAGE成独立负相关(P<0.05).结论 esRAGE可能是糖尿病动脉粥样硬化及代谢综合征的潜在保护因素.
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| 关 键 词： | 内源性分泌型糖基化终产物受体 2型糖尿病 颈动脉粥样硬化 代谢综合征 型糖尿病 患者血清 水平 负相关 因素研究 Diabetes Type Patients Related Factors Level Serum 保护因素 动脉粥样硬化 多元线性逐步回归分析 体质量指数 收缩压 低密度脂蛋白 总胆固醇 糖化血红蛋白 组成因素 |
Study on the Serum Level of esRAGE and Other Related Factors in Patients with Type 2 Diabetes |
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| FAN Hua-ying,CHENG Xing-bo,FAN Qing-tao.Study on the Serum Level of esRAGE and Other Related Factors in Patients with Type 2 Diabetes[J].Suzhou University Journal of Medical Science,2008,28(3). |
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| Authors: | FAN Hua-ying CHENG Xing-bo FAN Qing-tao |
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| Institution: | FAN Hua-ying,CHENG Xing-bo,FAN Qing-tao(Dept of Endocrinology,the First Hospital Affiliated to Suzhou University,Jiangsu Suzhou 215006,China) |
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| Abstract: | Objective To study the serum level of endogenous secretory receptor for advanced glycation end products(esRAGE) in type 2 diabetes(T2DM) and its relationship with other related factors.Methods Enzyme-linked immunosorbent assay(ELISA) was used to detect the serum esRAGE level in 60 T2DM 30 of which had carotid atherosclerosis and 28 normal controls,other clinical index was also tested.Results Serum esRAGE level was significantly lower in T2DM with carotid atherosclerosis than in T2DM without carotid atherosc... |
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| Keywords: | endogenous secretory receptor for advanced glycation end products type 2 diabetes carotid atherosclerosis metabolic syndrome |
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