99m^Tc-MIBI显像对甲状腺单发结节的诊断价值

目的：探讨99m^Tc-MIBI显像对甲状腺单发结节鉴别诊断的临床价值。方法：对甲状腺99m^TcO4-核素显像为单个＂冷结节＂的患者进行99m^Tc-MIBI显像,采集15min、30min及2h三时相的静态图像,将显像结果进行定量分析并与病理结果比较。结果：甲状腺癌组三时相的99m^Tc-MIBI摄取比值皆高于良性病变组（P〈0.001）;RI无显著性差异（P〉0.05）;T/N1组与T/N2组摄取比值无显著性差异（P〉0.05）。以甲状腺癌组摄取比值的（-x±s）为判断阈值,99m^Tc-MIBI显像对甲状腺癌诊断的灵敏度为75.00%-100.00%,特异性为81.25%-93.75%,准确性为84.09%-93.18%。T/N1组与T/N2组定量分析的灵敏度、特异性与准确性无显著性差异（P〉0.05）。结论：99m^Tc-MIBI显像对甲状腺单发结节良恶性鉴别诊断有较大的临床应用价值。

The diagnostic value of 99m^Tc-MIBI scintigraphy in the solitary thyroid nodules

Objective：To evaluate the clinical significance of 99m^Tc-MIBI scintigraphy in the solitary thyroid nodules.Methods： Total of 44 patients with solitary cold thyroid nodules visualized on 99m^Tc-pertechnetate scan were investigated.Three phases anterior static images were acquired after injection of 99m^Tc-MIBI 15min,30min,2h.Finally,quantitative analysis of the images were analyzed and compared with the pathological results.Results： Quantitative analysis showed the uptake ratio（UR） in the three phases were higher in malignant groups than that in begin groups（P〈0.001）.There were no significant differences in the retention index（RI） between malignant and begin lesions（P〉0.05）.There were no significant differences in the UR between T/N1 and T/N2（P〉0.05）.If the UR of malignant groups（x^-±s） was taken as the diagnostic threshold,the sensitivity,specificity and accuracy were 83.33%-100.00%,81.25%-93.75% and 86.36%-93.18%.There were no significant differences in the sensitivity,specificity and accuracy between T/N1 and T/N2（P〉0.05）.Conclusion： The thyroid 99m^Tc-MIBI scintigraphy has clinical significance in the differential diagnosis of solitary thyroid malignant nodules and begin lesions.