肝硬化患者血浆降钙素原、可溶性细胞间粘附分子-1检测及临床意义

观察肝硬化患者血浆降钙素原(PCT)、可溶性细胞间粘附分子-1(sICAM-1)水平变化及其各自临床意义.采用免疫发光法及ELISA法检测78例肝硬化患者及30例正常对照者血浆PCT、sICAM-1水平.肝硬化患者血浆PCT、slCAM-1水平显著高于正常对照组,失代偿期显著高于代偿期(均P＜0.01),随Child分级的增加,血浆PCT、sICAM-1水平逐渐升高.肝硬化患者血浆PCT水平与血清TBil水平呈正相关,与Pla呈负相关,与血清ALT水平无明显相关性;血浆slCAM-1水平与血清TBil、ALT水平呈正相关,与lra呈负相关.二者血浆水平可反映肝细胞损伤程度.

Detection and significance of plasma procalcitonin and soluble intercellular adhesion molecule - 1 in patients with liver cirrhosis

To observe the changes of plasma procalcitonin (PCT), soluble intercellular adhesion molcule-1(sICAM-1)levels in patients with liver cirrhosis (LC) and their clinical significance. Plasma PCT and sICAM-1 levels in 78 LC patients and in 30 normal controls (NC) were measured by immunoluminometric assay and ELISA, respectively. Plasma PCT?sICAM-1 levels of LC were significantly higher than those in NC, higher in decompensated phase than those in compensated phase (P<0.01) and with positive relationship. Plasma PCT?sICAM-1 levels increased gradually in pace with the progression of Child grading. Plasma PCT levels positively correlated with serum TBil levels, negatively correlated with PTa. Plasma sICAM-1 levels positively correlated with serum TBil and ALT levels, and negatively correlated with PTa. Plasma PCT sICAM-1 levels can reflect the degree of hepatocellular injury.