Inhibitory effect of S-adenosylmethionine on the growth of human gastric cancer cells in vivo and in vitro |
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| Authors: | Ye Zhao Jian-Sheng Li Ming-Zhou Guo Bai-Sui Feng Jin-Ping Zhang |
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| Affiliation: | Ye Zhao1,Jian-Sheng Li1,Ming-Zhou Guo2,Bai-Sui Feng1,Jin-Ping Zhang1 1 Department of Gastroenterology,the First Affiliated Hospital of Zhengzhou University,Key-Disciplines Laboratory Clinical-Medicine,Zhengzhou,Henan 450052,P. R. China,2 Department of Gastroenterology,the General Hospital of the People's Liberation Army,Beijing 100853 |
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| Abstract: | Background and Objective: S-adenosylmethionine (SAM), the most important methyl donor in human body, is generally used to treat cholestasis in clinic. In recent years, SAM has been found to have inhibitory effects on breast cancer, liver cancer and colon carcinoma. This study was to investigate the inhibitory effects of SAM on human gastric cancer cells in vivo and in vitro, and the antitumor mechanisms. Methods: The effects of SAM on the proliferation of gastric cancer SGC-7901 and MKN-45 cells were determ... |
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| Keywords: | S-adenosylmethionine gastric neoplasm nude mouse DNA methylation c-myc uPA |
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