| 实验性牙移动三叉神经节内神经生长因子受体mRNA的改变 |
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| 引用本文： | 徐娟,刘洪臣,袁维秀,黄旭明. 实验性牙移动三叉神经节内神经生长因子受体mRNA的改变[J]. 口腔医学研究, 2006, 22(2): 120-122 |
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| 作者姓名： | 徐娟 刘洪臣 袁维秀 黄旭明 |
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| 作者单位： | 解放军总医院口腔科,北京,100853;解放军总医院麻醉科 |
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| 基金项目： | 国家自然科学基金资助(编号:30572066)，全军医药卫生科研基金资助(编号:02M013) |
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| 摘 要： | 目的:观察实验性牙移动时,NGF受体-TrkA mRNA在三叉神经节内的改变,方法:采用RT-PCR方法研究实验性牙移动后,三叉神经节内TrkA mRNA表达的改变。结果:实验性牙移动后6 h,实验侧TrkA mRNA的表达开始增加;24 h、3 d,1周实验组三叉神经节内TrkA mRNA的表达强于对照组;2周组,实验侧TrkA mRNA的表达恢复至正常水平。结论:实验性牙移动时,三叉神经节内TrkA的表达升高。
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| 关 键 词： | 实验性牙移动 神经生长因子受体 |
| 文章编号： | 1671-7651(2006)02-0120-03 |
| 修稿时间： | 2005-11-07 |
Changes of NGF Receptor-TrkA mRNA Level in Trigeminal Ganglion during Experimental Tooth Movement in the Rat |
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| XU Juan,LIU Hong-chen,YUAN Weixiu,et al.. Changes of NGF Receptor-TrkA mRNA Level in Trigeminal Ganglion during Experimental Tooth Movement in the Rat[J]. Journal of Oral Science Research, 2006, 22(2): 120-122 |
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| Authors: | XU Juan LIU Hong-chen YUAN Weixiu et al. |
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| Affiliation: | XU Juan,LIU Hong-chen,YUAN Weixiu,et al.Department of Stomatology,General Hospital of PLA,Beijing 100853 |
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| Abstract: | Objective: To observe the changes of TrkA mRNA level in the trigeminal ganglion during the experimental tooth movement.Methods: The expressions of TrkA mRNA in trigeminal ganglion were tested by RT-PCR technology.Results: Comparing to the control group,the gene expression of the high-affinity NGF receptor,TrkA,was upregulated during the experimental tooth movement to a different extent and in a time-dependent manner.Expression of TrkA mRNA increased after 6 hours experimental tooth movement,then reached the highest at 24 hours and returned to control level after 2 weekes.Conclusion: The expression of TrkA increases in trgeminal ganglion after the experimental tooth movement. |
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| Keywords: | Experimental tooth movement NGF receptor |
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