|
|||||
|
|
A case of neurosarcoidosis with necrotizing granuloma expressing angiotensin-converting enzyme |
|
| Authors: | Shinji Kitajima Norihiko Sakai Kengo Furuichi Miki Tomokage Akinori Hara Kiyoki Kitagawa Seiko Sawada Kitamura Yoh Zen Mitsutoshi Nakada Shuichi Kaneko Takashi Wada |
| Affiliation: | 1. Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan 2. Department of Human Pathology, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan 3. Department of Neurosurgery, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan 4. Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan |
| Abstract: | We described a case of neurosarcoidosis with necrotizing sarcoid granulomatosis in a 22-year-old man. Contrast-enhanced brain computed tomography scan and magnetic resonance imaging showed intracerebral multiple nodular lesions. Noncaseating and partial necrotizing granulomas were detected in the specimen resected by neurosurgery. In addition, immunohistochemical examination revealed the expression of angiotensin-converting enzyme in necrotizing granuloma. Thus, these findings were consistent with neurosarcoidosis. Clinical and pathological presentation, immunological features, and treatment modalities of neurosarcoidosis are discussed. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |