A catalogue of polymorphisms related to xenobiotic metabolism and cancer susceptibility |
| |
Authors: | Gemignani Federica Landi Stefano Vivant Franck Zienolddiny Shanbeh Brennan Paul Canzian Federico |
| |
Affiliation: | Genome Analysis Group, International Agency for Research on Cancer, Lyon, France. |
| |
Abstract: | High-throughput genotyping technology of multiple genes based on large samples of cases and controls are likely to be important in identifying common genes which have a moderate effect on the development of specific diseases. We present here a comprehensive list of 313 known experimentally confirmed polymorphisms in 54 genes which are particularly relevant for metabolism of drugs, alcohol, tobacco, and other potential carcinogens. We have compiled a catalog with a standardized format that summarizes the genetic and biochemical properties of the selected polymorphisms. We have also confirmed or redesigned experimental conditions for simplex or multiplex PCR amplification of a subset of 168 SNPs of particular interest, which will provide the basis for the design of assays compatible with high-throughput genotyping. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|