Effects of surgical trauma on interleukin 2 production and interleukin 2 receptor expression |
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| Authors: | Li Hua Xiong Shu-tao Zhang Shou-xi Liu Shao-bin Luo Yi |
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| Affiliation: | (1) Department of Surgery, Xiehe Hospital, Tongji Medical University, Wuhan;(2) Department of Medical Molecular Biology, Research Center of Experimental Medicine, Tongji Medical University, Wuhan |
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| Abstract: | Summary To elucidate the mechanism of immunologic abnormalities induced by surgical trauma, we measured interleukin 2 (IL-2) production and IL-2 receptor expression in peripheral blood mononuclear cells from 16 patients with cholelithiasis. Compared with preoperative levels, IL-2 production and IL-2 receptor expression were significantly reduced on postoperative day 4, and the reduction was consistent with the suppression of lymphocyte proliferative response to phytohemagglutinin. |
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| Keywords: | surgical trauma interleukin 2 interleukin 2 receptor lymphocyte proliferation |
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