前列地尔对老年维持性血液透析患者微炎症状态的影响

目的 观察前列地尔注射液对老年维持性血液透析患者炎症指标的影响,探讨前列地尔注射液对老年MHD患者微炎症状态的治疗作用。方法将2013年6月—2014年3月该院收治的60例老年维持性血液透析患者随机分为2组：治疗组每次血液透析后给予前列地尔注射液10 ug静脉注射,对照组静脉注射等量生理盐水,疗程均为3个月,观察治疗前后患者炎症因子hs-CRP、IL-6、IL-10、TNF-α水平的变化。结果治疗组血浆hs-CRP水平治疗前（16.87±3.8）mg/L,治疗后下降至（12.38±2.94）mg/L;血浆IL-6水平治疗前（12.02±3.37）pg/m L,治疗后下降至（8.87±3.45）pg/m L;血浆IL-10水平治疗前（8.25±1.78）pg/m L,治疗后下降至（6.12±1.90）pg/m L;血浆TNF-α水平治疗前（26.52±1.89）pg/m L,治疗后下降至（18.01±2.12）pg/m L,且P〈0.05,提示治疗前后患者的炎症因子水平均显著降低,与对照组比较,差异有统计学意义（P〈0.05）。结论前列地尔注射液可以显著抑制维持性血液透析患者微炎症反应。

Effects of Prostaglandin E1 on the Microinflammatory State of the Elderly Patients with Maintenance Hemodialysis

Objective To observe and explore the effects of Prostaglandin E1 on the microinflammatory state of the elderly patients undergoing maintenance hemodialysis. Methods 60 elderly patients underwent maintenance hemodialysis were randomly divided into two groups, the treatment group and the control group. After each hemodialysis, the treatment group were given intravenous injection of Prostaglandin E1 10 ug, while the control group were given equivalent normal saline. The course of treatment of both groups was 3 months. And the levels of hs-CRP, IL-6, IL-10, TNF-α inflammatory factors in the patients before and after treatment were observed. Results Before treatment, the level of plasma hs-CRP, IL-6, IL-10, TNF-α of the treatment group was（16.87 ±3.8）mg/L,（12.02 ±3.37）mg/L,（8.25 ±1.78）mg/L,（26.52 ±1.89）mg/L,respectively, after treatment, the level of plasma hs-CRP, IL-6, IL-10, TNF-α decreased to（12.38±2.94）mg/L,（8.87±3.45）mg/L,（6.12±1.90）mg/L,（18.01±2.12）mg/L, respectively, P0.05, suggesting that the levels of inflammatory factors decreased significantly after treatment; and the differences between the treatment group and the control group were statistically significant（P0.05）. Conclusion Prostaglandin E1 can significantly inhibit the microinflammatory reactions of patients with maintenance hemodialysis.