降糖药物二甲双胍在癌症防治方面的新用途

二甲双胍是世界上应用最广范的抗糖尿病药物,而现在越来越多的证据证明这种药物具有潜在的抗癌功能。流行病学调查显示,使用二甲双胍治疗的糖尿病癌症患者发病率会降低。而且,二甲双胍能活化细胞能量感受器腺苷酸活化蛋白激酶(AMPK)途径,后者可以作为治疗癌症的最新靶点。最后,多项研究指出,二甲双胍能直接抑制癌细胞生长,具有抗肿瘤功能。

The new roles of Hypoglycemic drug metformin in cancer therapy

Metformin is the most widely used antidiabetic drug in the world,and there is an increasing evidence that this agent plays an important role in anti - caner therapy. Firstly, there is a decrease in cancer incidence in metformin - treated patients. Secondly, metformin activates the AMP activated protein kinase （AMPK） pathway,which has been proposed as a promising therapeutic target in cancer. Finally, metformin has a direct inhibitory effect on cancer growth and an antitumoral action.