c-kit在小细胞肺癌中的研究进展

小细胞肺癌约占全部肺癌的15％-20％,其因复杂的病理生理学特征和高度恶性引起了医学界的广泛关注。c-kit受体属于III型酪氨酸激酶受体家族,对某些正常细胞的分化、增殖、发育及功能维持起重要作用。近来研究发现小细胞肺癌组织有c-kit受体的异常表达,e-kit基因的突变,由此推测C-kit受体的异常表达及突变与小细胞肺癌的发生存在一定的关系。本文阐述了C-kit在小细胞肺癌中的研究进展。

Progress of e - kit in small cell lung cancer

Small - cell lung cancer（SCLC） accounts for 15 % N 20% of all lung cancer worldwide. Many medical scientists pay more attention to it, due to its pathophysiology feature and high malignancy. The c - kit pro- tein is a member of the type III receptor tyrosine kinase family. It promotes some normal cells differentiation, pro- liferation,and maintain cell function. Recent studies found that the expression and mutation of c - kit exist in small cell lung cancer samples. People presume that the mechanism of SCLC is relation to expression and mutation of c - kit. This article demonstrate the progression of c - kit receptor in SCLC.