血小板增多与恶性肿瘤的关系

近年来,恶性肿瘤病人的发病率和死亡率逐年上升。恶性肿瘤患者体内常出现血小板增多,血小板在恶性肿瘤的发病中起着重要作用。多种因素能导致血小板增高,临床上应该区分原发性血小板增多和继发性血小板增多,因为两者的治疗和预后差别较大。血小板增多与恶性肿瘤之间存在着密切关系,血小板可以被肿瘤细胞激发并活化,同时血小板又促进肿瘤细胞增殖、转移及血小板-肿瘤细胞栓子形成。血小板计数被认为是恶性肿瘤患者预后的又一个独立因素。控制血小板数目,应用血小板抑制剂可能会成为治疗肿瘤的又一药物,为恶性肿瘤的治疗带来新的希望。本文就血小板增多的原因及与恶性肿瘤之间的相互关系等方面做一简要综述。

Relationship between thrombocytosis and malignant tumor

In recent years, the morbidity and mortality of patients with malignant tumor has been increasing continually. The platelets significantly increased were in patient with malignant tumor in vivo. The platelets play an important role in the pathogenesis of malignant tumors. We should make a distinction between primary thrombocythemia and secondary cases thrombocytosis, because there are more difference in their treatment and prognosis. There was close relationship between thrombocythemia and patients with malignant tumor. The platelet could be excitated and activated by the malignant tumor cell. The platelet could promote tumor cell proliferation, metastasis and platelet tumour cell embolization. Blood platelet count be known as prognosis independence factor of patient with malignant tumor. We should control blood platelet count. It is possible that platelet suppressant drug treat malignant tumor. We briefly sum up cause of thrombocythemia and relationship with malignant tumor and so on.