踝臂指数联合超敏C反应蛋白对冠状动脉病变的判定价值

目的:探讨踝臂指数(ABI)联合超敏C反应蛋白(hs-CRP)对冠状动脉病变的判定价值。方法:选择2010-09-12期间住院并行冠状动脉造影的120例患者,收集行冠状动脉造影前ABI及hs-CRP的数值,根据冠状动脉病变狭窄程度(Gensini积分评价)及病变血管数量进行分组。结果:以ABI<0.9及hs-CRP>3mg/L为截断值,二者联合检测判定冠状动脉严重狭窄及多支病变的敏感度分别为85%和92%,特异度分别为69%和61%,与单用ABI或hs-CRP的方法比较,其敏感度均显著提高(均P<0.05),特异度有所下降。结论:ABI、hs-CRP的水平变化与冠状动脉的病变程度密切相关,对于冠状动脉严重狭窄及3支病变的判定,二者联合检测具有更高的实用价值。

Predictive value of ankle brachial index combined with serum highsensitivity C-reactive protein for extent of coronary artery disease

Objective:To investigate whether the combination of ankle brachial index(ABI) and serum high sensitivity C-reactive protein(hs-CRP) could improve their diagnosis value for extent of coronary artery disease(CAD) in patients. Method:The study population consisted of 120 patients scheduled to undergo elective cardiac catheterization for suspected CAD(from september 2010 to December).Collected data included ABI and hs-CRP before underwent coronary angiography.According to the degree of coronary stenosis(estimated by Gensini score) and the number of coronary artery stenosis,all subjects were divided into different groups. Result:With ABI <0.9 and hs-CRP >3 mg/L as the cutoff value,combined the 2 methods to predict serious stenosis and multi-vessel CAD,the sensitivity was respectively 85%,92%,and the specificity was respectively 69%,61%.Compared with using ABI or hs-CRP alone,the sensitivity of the 2 joint detection for predicting CAD increased significantly(P<0.05);the specificity decreased,but the difference was not statistically significant. Conclusion:ABI and hs-CRP are closely related to the extent of coronary artery disease,and the combination of ABI and hs-CRP may have higher practical value for predicting the extent of coronary artery disease.