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Relation of early post-stress left ventricular dyssynchrony and the extent of angiographic coronary artery disease |
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| Authors: | Wen-Sheng Huang MD Ching-Hui Huang MD Cheng-Liang Lee MD Ching-Pei Chen MD Guang-Uei Hung MD Ji Chen PhD FACC FASNC |
| Institution: | 1. Department of Nuclear Medicine, Changhua Christian Hospital, Changhua, Taiwan 6. Department of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan 2. Department of Cardiology, Changhua Christian Hospital, 135 Nan-Shiao Street, 500, Changhua, Taiwan 3. Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital, 135 Nan-Shiao Street, Changhua, 500, Taiwan 4. Department of Beauty Science, Graduate Institute of Beauty Science Technology, Changhua, Taiwan 5. Department of Nuclear Medicine, Chang-Bing Show Chwan Memorial Hospital, 6 Lukon Road, Lukong Town, Changhua, 505, Taiwan 7. Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan 8. Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA |
| Abstract: | BackgroundPrevious studies showed different dyssynchrony patterns between ischemic and normal myocardium at early post-stress using Tl-201 gated SPECT myocardial perfusion imaging (MPI). The aim of this study was to assess the relation of stress-induced dyssynchrony and the extent of angiographic coronary artery disease (CAD).Methods and ResultsThe MPI images of 144 patients were retrospectively analyzed. With ≥70% stenosis as the criteria of CAD, 57 had no CAD, 32 had 1-vessel disease, 36 had 2-vessel disease, and 19 had 3-vessel disease, respectively. LV global and territorial dyssynchrony parameters were measured by the phase analysis from stress/rest Tl-201 SPECT MPI and compared between stress and rest among the patient groups. The patients with multi-vessel CAD had significantly more global dyssynchrony than the patients without ≥70% stenosis at stress. The patients with multi-vessel CAD showed significantly more global and territorial dyssynchrony on stress images than on rest. More patients with 3-vessel CAD were correctly classified as multi-vessel disease, when combining both visual interpretation and dyssynchrony assessment.ConclusionThe patients with multi-vessel CAD had significantly more global and territorial dyssynchrony at early post-stress than at rest. Such quantitative measures of myocardial stunning may assist in the diagnosis of multi-vessel CAD. |
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