Molecular imaging of plaque vulnerability |
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Authors: | Sina Tavakoli MD Aseem Vashist MD Mehran M. Sadeghi MD |
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Affiliation: | 1. Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA 2. Section of Cardiology, University of Connecticut School of Medicine, Farmington, CT, USA 4. VA Connecticut Healthcare System, 950 Campbell Avenue, 111B, West Haven, CT, 06516, USA 3. Section of Cardiovascular Medicine and Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, USA
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Abstract: | Over the past decade, significant progress has been made in the development of novel imaging strategies focusing on the biology of the vessel wall for identification of vulnerable plaques. While the majority of these studies are still in the pre-clinical stage, few techniques (e.g., 18F-FDG and 18F-NaF PET imaging) have already been evaluated in clinical studies with promising results. Here, we will briefly review the pathobiology of atherosclerosis and discuss molecular imaging strategies that have been developed to target these events, with an emphasis on mechanisms that are associated with atherosclerotic plaque vulnerability. |
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