| 胃癌组织中端粒酶活性的检测 |
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| 引用本文： | Gao F,Zhang W,Jing S,Liu Y,Zhang B. 胃癌组织中端粒酶活性的检测[J]. 中国医学科学院学报, 1999, 21(4): 298-301 |
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| 作者姓名： | Gao F Zhang W Jing S Liu Y Zhang B |
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| 作者单位： | |
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| 基金项目： | 中华医学基金（CMB）资助 |
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| 摘 要： | 目的 检测中国人胃癌组织及相应癌旁组织中的端粒酶活性,探讨将其作为胃癌肿瘤标志物的可能性。方法 采用以ＰＣＲ为基础的ＴＲＡＰ（ｔｅｌｏｍ ｅｒｅ ｒｅｐｅａｔａｍ ｐｌｉｆｉｃａｔｉｏｎ ｐｒｏｔｏｃｏｌ）方法检测了４２ 例胃癌组织、４２ 例相应癌旁组织及１ 例胃溃疡伴肠上皮化生及轻度不典型增生组织中的端粒酶活性表达。结果 ４２ 例胃癌组织中,３７ 例显示端粒酶活性表达阳性,阳性率为８８１％ ;而在４２ 例相应癌旁组织中,仅有２ 例显示端粒酶活性表达阳性,１ 例胃溃疡伴肠上皮化生及轻度不典型增生组织端粒酶活性表达阳性。结论 以上结果提示端粒酶检测有可能成为胃癌辅助性诊断手段
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| 关 键 词： | 胃癌 端粒酶 |
Detection of telomerase activity in gastric cancer and adjacent tissues |
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| Gao F,Zhang W,Jing S,Liu Y,Zhang B. Detection of telomerase activity in gastric cancer and adjacent tissues[J]. Acta Academiae Medicinae Sinicae, 1999, 21(4): 298-301 |
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| Authors: | Gao F Zhang W Jing S Liu Y Zhang B |
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| Affiliation: | Department of Abdominal Surgery and Centre of Tumor Biology, Cancer Hospital, CAMS and PUMC, Beijing 100021. |
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| Abstract: | Objective To study the telomerase activity in chinese gastric cancer and their adjacent tissues and to explore the possibility of telomerase as a tumor biological marker. Methods Telomerase activity was analyzed in 42 primary gastric cancers and their adjacent tissues and 1 benign gastric lesion by a PCR based telomerase repeat amplification protocol assay. Results The result showed 88.1% (37/42) gastric cancerous specimens displayed telomerase activity. However, only 2 of 42 tissue samples adjacent to the gastric cancer showed telomerase activity. However our results indicated that 1 benign gastric lesion sample expressed telomerase activity Conclusions The results indicated that the detection of telomerase activity might be a useful method in the diagnosis of gastric cancer. |
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| Keywords: | gastric cancer telomerase |
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