| 三清降糖方的药效物质基础研究 |
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| 引用本文： | 吕立勋,李唐棣,王旭,吴范武,赵翠.三清降糖方的药效物质基础研究[J].中国实验方剂学杂志,2013,19(9):267-270. |
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| 作者姓名： | 吕立勋 李唐棣 王旭 吴范武 赵翠 |
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| 作者单位： | 1. 河北联合大学药学院,河北唐山,063000
2. 河北联合大学中医学院,河北唐山,063000 |
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| 基金项目： | 2011年唐山市科技支撑项目(1113020112a) |
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| 摘 要： | 目的:研究三清降糖方及各分离化学部位的对α-葡萄糖苷酶的抑制作用,对效应显著部位进行物质基础定性分析.方法:大孔吸附树脂分离制备各化学部位样品(JT-1～JT-13)；葡萄糖氧化酶法和淀粉耐量实验考察样品对α-葡萄糖苷酶活性的影响.结果:JT-1,JT-3,JT-6,JT-7部位对α-葡萄糖苷酶有显著抑制作用,其中JT-7部位对α-葡萄糖苷酶的抑制作用最显著.结论:生物碱和苷类成分可能是三清降糖方对α-葡萄糖苷酶的抑制作用的主要物质基础.
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| 关 键 词： | 三清降糖方 α-葡萄糖苷酶 物质基础 |
| 收稿时间： | 2012/8/15 0:00:00 |
Pharmacodynamic Material Basis of Sanqing Jiangtang Decoction |
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| L&#; Li-xun,LI Tang-di,WANG Xu,WU Fan-wu and ZHAO Cui.Pharmacodynamic Material Basis of Sanqing Jiangtang Decoction[J].China Journal of Experimental Traditional Medical Formulae,2013,19(9):267-270. |
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| Authors: | L&#; Li-xun LI Tang-di WANG Xu WU Fan-wu and ZHAO Cui |
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| Institution: | School of Pharmaceutical Sciences, Hebei United University, Tangshan 063000, China;School of Pharmaceutical Sciences, Hebei United University, Tangshan 063000, China;School of Pharmaceutical Sciences, Hebei United University, Tangshan 063000, China;College of Traditional Chinese Medicine, Hebei United University, Tangshan 063000, China;College of Traditional Chinese Medicine, Hebei United University, Tangshan 063000, China |
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| Abstract: | Objective: To evaluate the inhibitory activity of Sanqing Jiangtang decoction and chemical constituents on alpha glucosidase enzyme and to exploit the bioactive constituents. Method: The samples were prepared by macroporous adsorptive resins(JT-1-JT-13). Glucose oxidase method and starch tolerance test experiments were adopted to evaluate the inhibitory activity of Sanqing Jiangtang decoction and its different separated fractions. Result: It was found that fractions(JT-1,JT-3,JT-6,JT-7),separated from Sanqing Jiangtang decoction,mainly contributed to the inhibitory activity. JT-7 showed the most significant activities in the experiments. Conclusion: Glycosides and alkaloid may be the principle effective substance in the active fraction. |
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