高敏C反应蛋白、同型半胱氨酸和不稳定型心绞痛患者冠脉病变程度的相关性研究

目的探讨高敏C反应蛋白（hs-CRP）及同型半胱氨酸（Hcy）与不稳定型心绞痛（UA）患者冠脉病变程度的相关性。方法处纳入45例经冠脉造影证实的不稳定型心绞痛（UA）患者，31例经冠脉造影证实的非冠心病对照组患者，测定血脂、血糖、hs—CRP及Hcy，据冠脉造影结果，使用Gensini积分法将UA患者分组，评价hs—CRP及Hcy与UA患者冠状动脉病变程度的关系。结果UA患者hs—CRP及Hcy水平高于对照组，差异有统计学意义（p〈0．05），应用Logistic回归模型将混杂因素矫正后分析hs—CRP及Hcy与UA的关系时，hs—CRP与UA相关（p〈0．05）；hs—CRP及Hcy与UA患者冠脉病变程度无明显相关（p〈0．05）。结论（1）不稳定型心绞痛患者的Hcy和hs—CRP表达增加；（2）hs—CRP可能是UA的独立危险因素；（3）Hcy和hs—CRP增高的程度与冠脉病变狭窄程度无明显关联。

Correlation on Plasma Hcy and hs-CRP with Coronary Artery Lesion in UA

Objective Observe the correlation on plasma homocystein （Hcy） and high-sensitivity c-reactive protein （hs-CRP） with coronary artery lesion in unstable angina pectoris（UA） patients.Methods we recruited 45 inpatients with UA and 31 subjects had completely normal coronary arteries.being submitted to coronary angiography.All patients were detected homocysteine,blood glucose,blood lipids,hs-CRERecorded coronary disease vessel number count and coronary stenosis degree by checking coronary angiography.The severity of coronary stenosis also evaluated by using the Gensini scoring system.Results The plasma Hcy and hs-CRP Levels of the UA group was higher than the levels of the control group （P 〈 0.05）. Multivariate analysis also indicated relationship between hs-CRP and UA. In UA group,there was no significant difference between number of coronary vessel disease and Hcy or hs-CRP.Conclusion （ 1）The plasma Homocysteine and hs-CRP levels of patients with UA were significantly increased. （2） There was no significant difference between number of coronary vessel disease and Hey or hs-CRP.