| 榆林大骨节病区水中黄腐酸对培养软骨细胞作用的观察 |
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| 引用本文： | 曹峻岭,黄辰.榆林大骨节病区水中黄腐酸对培养软骨细胞作用的观察[J].中国地方病防治杂志,1998,13(2):70-72. |
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| 作者姓名： | 曹峻岭 黄辰 |
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| 作者单位： | 西安医科大学地方性骨病研究所
(曹峻岭，郭雄，毕华银，张矢远)，西安医科大学生物学、遗传学教研室
(黄辰)，西安医科大学地方性骨病研究所(莫东旭) |
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| 基金项目： | “八五”国家科技攻关85—917—01—02项目 |
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| 摘 要： | 目的；本实验观察黄腐酸（ＦＡ）对软细胞，结构，生长，代谢和功能的影响，方法：用大骨节病病区水中ＦＡ，以不同浓度（５ｍｇ／Ｌ，１０ｍｇ／Ｌ，２０ｍｇ／Ｌ）作用于体外培养的兔关节软骨细胞，检测结果作Ｆ检验进行统计学处理，结果：显示实验组织细胞膜功能，蛋白质，ＤＮＡ，蛋白聚糖等不低于对照组或高于对照组，结论：ＦＡ对培养软骨细胞的ＤＮＡ合成，分裂增殖和细胞结构等没有影响。
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| 关 键 词： | 黄腐酸 软骨细胞 培养 大骨节病 |
THE EFFECTS OF FULVIC ACID IN THE DRINKING WATER OF KASH1N-BECK DISEASE REGION ON THE CULTURAL CHONDROCYTES |
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| Cao Junling
Institute of Endemic Hone Diseases,Xi''''an Medical University,Xi''''an.THE EFFECTS OF FULVIC ACID IN THE DRINKING WATER OF KASH1N-BECK DISEASE REGION ON THE CULTURAL CHONDROCYTES[J].Chinese Journal of Control of Endemic Disenaces,1998,13(2):70-72. |
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| Authors: | Cao Junling
Institute of Endemic Hone Diseases Xi'an Medical University Xi'an |
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| Abstract: | To observe the effects of fulvic acid(FA)on the growth,metabolism and ultrastructure of the chondrocytes. Methods: The experiment by culturing rabbit articular chondrocytes in the media containing different contents of FA(5mg/L,10mg/L,20mg/L)obtained from the drinking water of Kashin -Beck disease and no disease region. The data were statistically treated by F test. Results:The FA in the culyural media showed no restraint effect on the DNA synthesis and cellular growth of chondrocytes, and no effects on the ultrastructure and the glucuronate metabolish of the chondrocytes were seen as well. Conclusion:The FA did not affect the growth,metabolism and ultrastructure of the cultural chondrocytes. |
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| Keywords: | Y Psstis Plant Nutrition requirement |
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