| 小儿急性白血病细胞染色体分析及其与临床预后关系的探讨 |
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| 引用本文： | 李祯萍,王易,柴忆欢,王津媛,何军,何亚香. 小儿急性白血病细胞染色体分析及其与临床预后关系的探讨[J]. 中国小儿血液与肿瘤杂志, 1998, 0(6) |
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| 作者姓名： | 李祯萍 王易 柴忆欢 王津媛 何军 何亚香 |
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| 作者单位： | 苏州医学院附属儿童医院血液科(李祯萍，王易，柴忆欢，王津媛)，苏州医学院附属儿童医院儿科研究室(何军，何亚香) |
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| 摘 要： | 为探讨白血病患儿细胞遗传学改变和临床预后的关系，我们对41例急性白血病初诊患儿进行细胞遗传学研究，28例异常核型检出（68％），其中急性淋巴细胞白血病异常核型检出率为67％，急性非淋巴细胞白血病异常核型检出率为73％。急性白血病患儿染色体结构异常可视为预后不佳的标志，而正常二倍体核型及超二倍体核型的白血病（尤其是超过50条的急淋）则预后较好，还对其中11例患儿核型进行动态观察，提示细胞遗传学研究可作为白血病患儿诊断分型、指导治疗和判断预后的重要指标。
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| 关 键 词： | 白血病 急性 核型 |
CYTOGENETIC ANALYSIS AND ITS CLINICAL SIGNIFICANCE IN CHILDHOOD ACUTE LEULEMIA |
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| Abstract: | Cytogenetic analysis were performed in 41 Childhood acute leukemia. Chromosomeaberrations were identified in 68% of the patients. Abnormal chromosomal patterns were revealed in 67% of patients with ALL and 73% of patients with ANLL. The correlation between karyotype and shore-term therapeutic results was investigated in patients with AL.We found that those with structural abnormality had poor prognosis and those with normaland hyperdiploidy (over 50)karyotypes showed favorable manifestations and therapeutic results. Serial observations in the course of disease were conducted on bone marrow karyotypesin 11 patients. We conclude that cytogenetic study on leukemia cells is of great value in diagnosis, prediction of prognosis and guidance for treatment in patients with acute leukemia. |
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