| 载万古霉素-PDLLA内植物的生物学安全性评估 |
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| 引用本文： | 唐良华,赵长虹,王爱民. 载万古霉素-PDLLA内植物的生物学安全性评估[J]. 生物医学工程研究, 2009, 28(2): 108-111 |
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| 作者姓名： | 唐良华 赵长虹 王爱民 |
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| 作者单位： | 1. 第三军医大学大坪医院野战外科研究所骨科,重庆,400042
2. 重庆大学生物工程学院生物材料与仿生工程研究中心,重庆,400044 |
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| 摘 要： | 检测载万古霉素-PDLLA(聚-DL-乳酸)内植物的生物安全性.以PDLLA为载体,采用溶剂浇铸技术,在钛合金板基体表面制备了携载万古霉素的PDLLA抗感染涂层,参考医疗器械生物学评价标准,通过全身急性毒性试验,热原试验,溶血试验等来检测其生物相容性.结果表明:载万古霉素-PDLLA内植物各项生物学指标均合格,其组织相容性、血液相容性良好,无全身毒性和细胞毒性,对皮肤无刺激作用,对机体组织无潜在的致敏性,没有致突变作用.说明载万古霉素-PDLLA内植物具有良好的生物相容性.
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| 关 键 词： | 万古霉素 聚-DL-乳酸 溶剂浇铸技术 涂层 生物学安全性评价 |
Evaluation on Biological Safety of Vancomycin-PDLLA Loaded Antibacterial Plates |
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| TANG Lianghua,ZHAO Changhong,WANG Aimin. Evaluation on Biological Safety of Vancomycin-PDLLA Loaded Antibacterial Plates[J]. Journal Of Blomedical Englneerlng Research, 2009, 28(2): 108-111 |
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| Authors: | TANG Lianghua ZHAO Changhong WANG Aimin |
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| Affiliation: | 1.Dept.of Orthopedics;Daping Hospital;The Third Military Medical University;Chongqing 400042;China;2.The Bioengineering Department;Chongging University;Changqing 400044 |
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| Abstract: | To evaluate the biological safety for an internal fixation plate which can inhibit infection by carrying and slow-releasing Vancomycin.PDLLA coating which carrying Vancomycin were prepared on the surface of titanium plate substrate for fracture fixation by solvent casting technology with the PDLLA as a carrier;the biological safety of Vancomycin-PDLLA loaded plates were investigated by acute systemic toxicity test,hemolytic test,pyrogen test,et al.Results showed that there were no toxicity(cytotoxicity,syst... |
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| Keywords: | Vancomycin PDLLA Solvent casting technology Coating Biological evaluation |
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