P63蛋白在甲状腺肿瘤中表达的意义

目的:探讨p63蛋白在甲状腺腺瘤、甲状腺乳头状癌、甲状腺滤泡癌、鳞状细胞癌和甲状腺髓样癌中的表达意义,探索这些甲状腺疾病的可能起源,以及这些疾病病因之间有无联系。方法:运用免疫荧光法检测10例甲状腺腺瘤、25例甲状腺乳头状癌、4例甲状腺滤泡状癌、2例髓样癌和2例甲状腺鳞状细胞癌中p63的表达。结果:p63在甲状腺腺瘤、甲状腺乳头状癌、甲状腺滤泡癌、甲状腺鳞状细胞癌和甲状腺髓样癌中均有表达。p63在鳞状细胞癌和髓样癌中表达最高,在甲状腺乳头状癌中其表达与患者年龄、性别、肿块位置、肿块大小和有无转移无明显相关性。结论:①甲状腺组织内存在p63阳性标记的干细胞;②甲状腺乳头状癌、滤泡癌、鳞状细胞癌等可能起源相似。干细胞是多功能细胞,向不同方向分化,形成不同疾病;③p63在甲状腺鳞状细胞癌和髓样癌中表达最高,说明在鳞状细胞癌中残留干细胞较多,与肿瘤的生物学特性一致。

The significance of p63 expression in thyroid neoplasm

Objective:To explore the significance of p63 expression in thyroid carcinoma,thyroid papillary carcinoma,thyroid follcular carcinoma,squamous cell carcinoma and medullary thyroid carcinoma in order to find the possible causes of such thyroid-related diseases and if there is some kind of relation among them.Method:The expression of p63 was examined in 10 thyroid carcinomas,20 thyroid papillary carcinomas,4 thyroid follcular carcinomas,2 squamous cell carcinomas and 2 medullary thyroid carcinomas using direct immunofluorescence.Result:It was shown that p63 expressed in all the thyroid-related diseases mentioned above.In squamous cell carcinoma,p63 has the highest expression and the expression of p63 in thyroid papillary carcinoma has no obvious relationship with the patients' age,sex,the size and location of tumor and neoplasm metastasis.Conclusion:The p63 masculine stem cells in thyroid could be one of the causes of some thyroid papillary carcinomas and thyroid follcular carcinomas.Thyroid papillary carcinoma,thyroid follcular carcinoma and squamous cell carcinoma may have similar origins.