Histamine release by platelet aggregation. |
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| Authors: | P F Mannaioni B Palmerani A Pistelli F Gambassi E Giannella T Bani Sacchi E Masini |
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| Affiliation: | Department of Preclinical and Clinical Pharmacology, University of Florence, Italy. |
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| Abstract: | Coincubation of rat serosal mast cells with human platelets leads to a significant release of histamine. which dose-dependently increases when platelet aggregation is induced by various concentrations of arachidonic acid. In turn, histamine enhances platelet aggregation induced by different agonists, this effect being mimicked by pyridyl-ethyl-amine (PEA), blocked by mepyramine and amplified by ranitidine. The data suggest the existence of a platelet-derived histamine releasing factor (PDHRF) and indicate the presence of platelet H1 and H2 receptors, capable of modulating platelet aggregation. |
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