不同程度动脉粥样硬化病变中弹力纤维的形态及含量改变

为探讨不同动脉粥样硬化程度病变中弹力纤维的形态及含量改变，对２１例中青年猝死者腹主动脉的正常内膜，脂斑脂纹和纤维斑块进行电镜观察，发现正常内膜弹力纤维呈条索状，而脂斑脂纹和纤维斑块中的弹力纤维呈斑片状，弹力纤维含量在脂斑脂纺中最多，正常内膜次之，纤维斑块中最少，三组之间相比较差异具显著性（Ｐ〈０．０１），提示随动脉继榇硬化的发展，病变中弹力纤维不仅有形态学改变，其含量也有明显改变。

The Morphological and Content Change of Elastic Fiber in Different Stages of Atherosclerotic Lesions

Aim: To study the morphological and quatitative change of elastic fiber in different stages of atherosclerotic lesions.Methods: The normal intima, fatty streaks and fibrous plaques, from 17 abdominal aortae of young men of nom-cardiovascular sudden death were observed with electrolic microscope.Results: The elastlc flber in normal intima appeared to be cord-like, while the e1astic fiber in the fatty streaks and fibrous plaques appeared to be patch-like.The content of elastic fiber was highest ln the fatty streaks, the lowest in the fibrous plaques. The elastic fiber content of normal intima was between the fatty streaks and fibrous plaques. The differences of elastic fiber content among three groups were statistically significant (P<0. 01 ).Conclusion: With the developement of atherosclerosls, the elastlc fiber has not only morphological changes but also content change. This indicate that the elastic fiber plays a very irnportant role in the formation and developement of atherosclerosis.