Automated system for on-line desorption of dried blood spots applied to LC/MS/MS pharmacokinetic study of flurbiprofen and its metabolite |
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| Authors: | Julien Dé glon,Auré lien Thomas,Youssef Daali,Estelle Lauer,Caroline Samer,Jules Desmeules,Pierre Dayer,Patrice Mangin,Christian Staub |
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| Affiliation: | 1. Unit of Toxicology, University Center of Legal Medicine, Geneva, Switzerland;2. Division of Clinical Pharmacology and Toxicology, Geneva University Hospitals, Geneva, Switzerland;3. Swiss Centre for Applied Human Toxicology, University of Geneva, Geneva, Switzerland |
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| Abstract: | This paper illustrates the development of an automated system for the on-line bioanalysis of dried blood spots (on-line DBS). In this way, a prototype was designed for integration into a conventional LC/MS/MS, allowing the successive extraction of 30 DBS toward the analytical system without any sample pretreatment. |
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| Keywords: | On-line DBS Automated system LC/MS/MS Flurbiprofen Pharmacokinetic |
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