Effect of sodium fluoride on bone tissue regeneration in hypodynamia]

It was demonstrated in rat experiments that a nonsupported position of the extremity attained by exarticulation of the leg in 10 to 40 days leads to a sharp inhibition of posttraumatic regeneration of bone tissue. Daily injection of 0.4 mg/100 g sodium fluoride, which was used in the clinic for the prevention and treatment of osteoporosis, inhibited still more the regenerative processes both under conditions of hypodynamia and also when the supporting function of the extremity was maintained.