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The structural gene for aldolase B (ALDB) maps to 9q13→32 |
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| Authors: | I HENRY &#; P GALLANO&#; C BESMOND† D WEIL† M G MATTEI‡ C TURLEAU§ J BOUÉ&#; A KAHN C JUNIEN &#; ¶ |
| Institution: | *Institut de Génétique et de Pathologie Moléculaires INSERM U.129, 24, rue du Fbg Saint Jacques 75674 Paris Cedex 14; †Unitéde Recherches de Génétique Médicale, INSERM U.12, 149, rue de Sèvres, 75730 Paris Cedex 15;‡Centre de Génétique Médicale, INSERM U.242, Hôpital d'Enfants de la Timone, 13385 Marseille Cedex 05;§Laboratoire de Cytogénétique Humaine et Comparée. INSERM U.173 CNRS ER.149, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75730 Paris Cedex 15;‖Groupe de Recherches de Biologie Prénatale, INSERM U.73, Château de Longchamp, Bois de Boulogne, 75016 Paris |
| Abstract: | We used a cloned cDNA probe for the B subunit of human aldolase (ALDB) and Southern blotting techniques to analyse DNA from a series of rodent x human somatic cell hybrids for the presence of specific ALDB-related sequences. Our results provide evidence for the assignment of the gene for ALDB to chromosome 9. Moreover, by direct gene dosage determination in two patients with chromosome 9 unbalanced rearrangements and by in situ hybridization we refined the regional chromosomal assignment to 9q13→q32 and most probably to 9q21.3→9q22.2. |
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