薯藤多糖降血脂作用实验研究

目的:观察薯藤多糖(STDT)在高脂动物模型上的降血脂作用。方法:SD大鼠、新西兰家兔采用高脂饲料喂养法、ICR小鼠采用腹腔注射蛋黄乳法复制高脂模型,分别灌胃给予不同剂量的STDT,测定给药前或给药后不同时间血清TC、TG、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)等指标。结果:STDT250、500、1000mg/kg剂量灌胃给药4周可明显抑制食糜性高脂大鼠血清TC、TG以及LDL-C的升高;100、200、400mg/kg剂量灌胃给药4周,能明显降低食糜性高脂家兔的血脂水平,使其血清TC、TG、LDL-C明显下降;STDT400、800、1600mg/kg剂量给药3d,对腹腔注射蛋黄乳所致的高脂模型小鼠血脂也有一定的降低趋势。结论:STDT无论是预防给药或是治疗给药,对多种高脂模型动物均体现出一定的降脂作用。

Experimental study of koali vine polysaccharides on reducing blood lip-ids

AIM:To observe the effects of koali vine polysaccharides(STDT)on reducing blood lipids in hyperlipidemic animal model.METHODS:The hyperlipidemic animal model of SD rats,New Zealand rabbits and ICR mice were induced by feeding high cholesterol food and injecting intraperitoneally egg yolk,and then were administered intragastrically with different doses of STDT.The levels of TC,TG,high-density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)in serum were measured at different time before and after administration.RESULTS:STDT could restrain the increase of TC,TG and LDL-C in high-lipid model rats serum after oral administration for four weeks at the dosages of 250,500 and 1000 mg/kg,and degrade the blood fat level of high-lipid model,decrease the levels of TC,TG and LDL-C in rabbits serum obviously at the dosages of 100,200 and 400 mg/kg.In addition,the high-lipid ICR mice which were administered with STDT for three days showed a decreasing tendency on blood lipids at the dosages of 400,800,1600 mg/kg.CONCLUSION:The results suggest that STDT has a reducing blood lipids effects on many high-lipid animal models for prevention or treatment.