Amyloidosis localized in the sigmoid colon |
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Authors: | Hidetaka Matsui Tetsuya Kato Gaku Inoue Morikazu Onji |
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Institution: | (1) Department of Internal Medicine, Uwajima Social Insurance Hospital, 2-1-37 Kako-cho, 798 Uwajima-shi, Ehime, Japan;(2) Third Department of Internal Medicine, Ehime University, School of Medicine, Shitsukawa, Shigenobu-cho, 791-02 Onsen, Ehime, Japan |
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Abstract: | A 79-year-old woman was admitted to our hospital presenting with bloody stool. Colonoscopic examination showed many irregularly-shaped
discrete ulcerations in the sigmoid colon extending for a length of 6cm, situated 16cm proximal to the anl ring. Histopathology
of the biopsy specimen in and around the ulcerations revealed the deposition of amyloid materials in the proper mucosa and
the submucosa. Similar ulcerations were not detected by endoscopy in other parts of the gastrointestinal tract, i.e., esophagus,
stomach, and duodenum. Multiple biopsy specimens taken from various parts of the gastrointestinal tract other than the sigmoid
colon showed no amyloid deposition. Further investigations showed no particular abnormality in any organs and the patient
was free of such systemic disease as myeloma or collagen disease. The findings were consistent with those of localized sigmoid
amyloidosis. Localized colonic amyloidosis is rare, this being the fifth patient reported in Japan in the past 15 years. |
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Keywords: | localized colonic amyloidosis bloody stool ulceration |
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