临床药师参与1例肥胖患儿颅内曲霉菌感染的药物治疗

目的:探讨儿科临床药师在肥胖患儿颅内曲霉菌感染治疗中的作用。方法:临床药师通过参与1例肥胖患儿颅内曲霉菌感染的药物治疗实践，调整肥胖患儿用药方案，监测抗真菌药物血药浓度、检测代谢基因并调整剂量，降低了药物不良反应发生率。结果:经过1个月抗感染治疗，患儿病情好转出院。结论:对于罕见颅内曲霉菌感染肥胖患儿，临床药师进行了个体化药物治疗，保障了儿童用药的安全性和有效性。

Drug Therapy Analysis of Clinical Pharmacist Participating in a Case of Intracranial Aspergillus Infection

Objective: To explore the role of clinical pharmacists in the treatment of intracranial Aspergillus infection in obese children. Methods: Clinical pharmacists participated in the drug therapy of intracranial Aspergillus infection in an obese child, recommended the initial dose of the obese child, monitored the blood concentration of voriconazole, detected metabolic genes and adjusted the dose, which reduced the incidence of adverse drug reactions related to voriconazole. Results: After 1 month of anti-infection treatment, the child was discharged from hospital with improved condition. Conclusion: For rare intracranial Aspergillus infection, clinical pharmacists should carry out individualized drug therapy for obese children to ensure the medication safety and effectiveness for children.