The role of 5-HT3 receptors in the anti-ulcer effect of calcitonin |
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| Affiliation: | 1. Department of Pharmaceutical Chemistry, Bharati Vidyapeeth''s College of Pharmacy, Navi Mumbai, Maharashtra, India;2. Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Germany;3. The Cytometry, Screening and Imaging Core Facility & Border Biomedical Research Center & Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA;4. Department of Biophysics and Human Physiology, Medical University of Warsaw, Chalubinskiego, Warsaw, Poland;5. East Carolina Diabetes and Obesity Institute, Department of Chemistry, East Carolina University, Greenville, North Carolina, USA;6. Department of Biochemistry and Molecular Biology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA;1. Department of Pharmaceutical Chemistry, Telangana University, Dichpally, Nizamabad, Telangana State 503322, India;2. Department of Physics, University P.G. College, Satavahana University, Godavarikhani, Telangana State 505209, India;3. Department of Chemistry, Satavahana University, Karimnagar, Telangana State 505001, India;4. Department of Pharmacology and Toxicology, UCPSc, Kakatiya University, Warangal, 506009, Telangana State, India;5. Department of Physics, Kakatiya University, Warangak, Telangana State 506009, India;1. Department Life Sciences, University of Modena and Reggio Emilia, Modena, Italy;2. Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy;3. Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, London, United Kingdom;4. King''s College, Department of Women & Children''s Health Great Maze Pond, London, United Kingdom |
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| Abstract: | - 1.1. The aim of the present study was to determine the role of 5-HT3 receptors of the gastroprotective effect of salmon calcitonin (sCT) and sCT-induced changes in gastric, hepatic, brain and brainstem glutathione (GSH) and lipid-peroxidation (LP) levels in rats subjected to cold-immobilization stress.
- 2.2. Stress exposure resulted in ulcer formation and a decrease in GSH levels of the liver, brain and brainstem and an increase in gastric and hepatic LP (P <0.05).
- 3.3. sCT prevented stress-induced gastric ulcer development (P < 0.01) and reversed the decrease in hepatic and brain GSH levels (P < 0.05).
- 4.4. In the present study, a 5-HT3 receptor antagonist, ICS 205 930 was used. Interestingly, the effect of the blocker on GSH and LP levels of the tissues studied was similar to those of sCT.
- 5.5. ICS 205 930 dose dependently reversed the anti-ulcer effect of sCT although it did not antagonize the effect of sCT on GSH and LP levels, but it seemed to show an additive interaction for brain and brainstem GSH and gastric LP levels with sCT.
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