Interactions of ginsenosides with ligand-bindings of GABAA and GABAB receptors |
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| Affiliation: | 2. Royal Belgian Institute of Natural Sciences, Rue Vautier 23, 1000 Brussels, Belgium;1. Laboratorio de Contaminación y Toxicología, Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, Nayarit, Mexico;2. Posgrado en Ciencias Biológico Agropecuarias, Universidad Autónoma de Nayarit, Tepic, Nayarit, Mexico;3. Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del IPN, México, D.F., Mexico |
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| Abstract: | - 1.1. Total saponin fraction decreased the affinity of specific [3H]muscimol binding without changes in Bmax. Ginsenoside Rb1 Rb2, Rc, Re, Rf and Rg1 inhibited the specific [3H]muscimol binding to the high-affinity site.
- 2.2. Total saponin fraction increased the affinity of specific [3H]flunitrazepam binding. Ginsenoside Re and Rf enhanced specific [3H]flunitrazepam binding.
- 3.3. Total saponin fraction decreased the affinity of specific [35S]TBPS binding without changes in Bmax. Ginsenosides did not affect specific or non-specific [35S]TBPS binding.
- 4.4. Total saponin fraction decreased the affinity of specific [3H]baclofen binding without changes in Bmax. Ginsenoside Rc inhibited specific [3H]baclofen binding.
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