Gender and test dependence of a type of kappa mediated stress induced analgesia in mice |
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| Affiliation: | 1. Laboratorio de Farmacología, Departamento de Medicina, Facultad de Medicina, Universidad de Oviedo, Julián Clavería s/n, 33071 Oviedo, Asturias, Spain [Tel. 34-8-5103551; Fax 34-8-5232255];2. Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain;1. National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA;2. Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21218, USA;3. Harvard Medical School, Boston, MA 02115, USA;4. Department of Psychiatry & Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA;1. Université Grenoble Alpes, INSERM, U1216, CHU Grenoble Alpes, CNRS, Grenoble Institut Neurosciences, 38000 Grenoble, France;2. Université Grenoble Alpes, CNRS, Grenoble INP, GIPSA-Lab, 38000 Grenoble, France;3. Université Grenoble Alpes, Inria, CNRS, Grenoble INP, LJK, 38000 Grenoble, France;1. Department of Pharmacology, Nihon University School of Dentistry, 1-8-13, Japan;2. Division of Oral and Craniomaxillofacial Research, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan;3. Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan;1. Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100083, P.R. China;2. Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing 100021, P.R. China;3. Chinese Institute for Brain Research, Beijing 102206, P.R. China;4. Department of Civil Engineering, Tsinghua University, Beijing 100084, P.R. China;5. Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China;6. Key Laboratory for Neuroscience, Ministry of Education / National Health Commission, Peking University, Beijing 100083, P.R. China;7. Department of Traditional Chinese Medicine, Peking University Third Hospital, Beijing 100191, P.R. China;1. Experimental Center for Medical Research, School of Anesthesiology, Weifang Medical University, Weifang 261053, China;2. School of Psychology, Weifang Medical University, Weifang 261053, China;3. Department of Anesthesiology, Weifang People''s Hospital, Weifang 261044, China;1. Affiliated Psychological Hospital of Anhui Medical University, Hefei Fourth People’s Hospital, Anhui Mental Health Center, Hefei, China;2. Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China;3. Department of Pathology, Anhui Medical College, Hefei, China;4. Department of Otolaryngology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China;5. Department of Anatomy, Medical College of Taizhou University, Taizhou, China;6. Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China |
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| Abstract: | 1. In male mice, 80 inescapable footshocks (S-80) induce analgesic responses measured by the tail flick test that are blocked by naloxone and the kappa opioid antagonist, nor-binaltorphimine. We now study the nociceptive responses, induced after this particular stress, measured by the writhing test, the tail immersion test and a high intensity tail immersion test both in male and female mice.2. In stressed males, analgesic responses are seen in all the nociceptive tests. Naloxone (10 mg/kg) does not prevent them.3. In stressed females, in contrast with males, no analgesia is produced in the tail flick test. The writhing test and the tail immersion test registered analgesic responses that were not prevented by naloxone (10 mg/kg).4. We conclude that only the antinociceptive kappa opioid mediated component of the stress we study is strongly dependent on gender, in contrast to other types of analgesia triggered by the same stress. |
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