The effect of allopurinol on the liver ultrastructure,reduced glutathione and lipid peroxide levels during liver ischemia in guinea pigs |
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| Affiliation: | 1. Department of General Surgery, Faculty of Medicine, University of Gazi, Becsevler, Ankara, Türkiye Turkey;2. Department of Biochemistry, Faculty of Medicine, University of Gazi, Beşevler, Ankara, Türkiye Turkey;3. Department of Biology, Faculty of Education, University of Gazi, Beşevler, Ankara, Türkiye Turkey;4. Department of Biology, Faculty of Science, University of Ankara, Tandoǧan, Ankara, Türkiye Turkey [Fax: 90 (312) 213 43 38];1. School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland;2. Department of Internal Medicine Specialties, Faculty of Medicine, University of Geneva, Geneva, Switzerland;3. Swiss Centre for Applied Human Toxicology (SCAHT), Universities of Basel and Geneva, Switzerland;4. Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland;1. Service de dermatologie, hôpital Henri-Mondor, AP–HP, 94000 Créteil, France;2. Centre de référence dermatoses bulleuses toxiques et toxidermies graves TOXIBUL, filière FIMARAD, hôpital Henri-Mondor, AP–HP, 94000 Créteil, France;3. Université Paris Est Créteil EpiDermE, 94000 Créteil, France;4. Centre de traitement des brûlés, hôpital d’instruction des Armées Percy, 92140 Clamart, France;5. Service de réanimation médicale, hôpital Henri-Mondor, AP–HP, 94000 Créteil, France |
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| Abstract: | 1. The preventive effect of allopurinol on reduced glutathione and lipid peroxide levels of the liver and the accompanying ultrastructural changes during liver ischemia was investigated in guinea pigs.2. Liver glutathione levels decreased significantly while lipid peroxide levels increased slightly in the ischemic group.3. Allopurinol administered before ischemia resulted in a reverse significant increase in liver glutathione levels and a significant decrease in lipid peroxide levels indicating a protective effect upon cell membrane during ischemia.4. On the other hand, electron microscopic changes in the liver associated with ischemia could not be altered by allopurinol. |
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