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From the organ bath to the whole person: a review of human colonic motility |
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| Authors: | David A. Wattchow BM BS PhD FRACS Simon J. Brookes PhD Nick J. Spencer PhD Paul T. Heitmann MD PhD Roberto De Giorgio MD PhD Marcello Costa MD FAA AO Phil. G. Dinning PhD |
| Affiliation: | 1. College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia Departments of Surgery and Gastroenterology, Flinders Medical Centre, Adelaide, South Australia, Australia Contribution: Conceptualization, Writing - original draft, Writing - review & editing;2. College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia;3. Department of Translational Medicine, University of Ferrara, Ferrara, Italy |
| Abstract: | Motor function of the colon is essential for health. Our current understanding of the mechanisms that underlie colonic motility are based upon a range of experimental techniques, including molecular biology, single cell studies, recordings from muscle strips, analysis of part or whole organ ex vivo through to in vivo human recordings. For the surgeon involved in the clinical management of colonic conditions this amounts to a formidable volume of material. Here, we synthesize the key findings from these various experimental approaches so that surgeons can be better armed to deal with the complexities of the colon. |
| Keywords: | colon enteric nervous system in vivo motility organ bath |