Decreased natural killer (NK) cell activity in zinc-deficient rats |
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| Affiliation: | 1. Key Laboratory of Coalbed Methane Resources and Reservoir Formation Process of the Ministry of Education, China University of Mining and Technology, Xuzhou, Jiangsu 221000, China;2. School of Resources and Geosciences, China University of Mining and Technology, Xuzhou 221116, China;3. Yunnan Institution of Coal Geology Prospection, Kunming 650218, China;4. School of Management, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China;5. Oujiang College, Wen Zhou University, Wenzhou, Zhejiang 325035, China;1. Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China;2. Jiangxi Province Institute of Veterinary Drug and Feed Control, Nanchang 330029, Jiangxi, PR China;1. Department of Electronics and Communication Engineering, Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham– 641112, India;1. Institutes of Biology and Medical Science, Soochow University, Suzhou 215123, China;2. Critical Illness Research, Lawson Health Research Institute, Canada;3. Department of Medicine, University of Western Ontario, London, Ontario N6A 4G5, Canada;4. Department of Pathology, University of Western Ontario, London, Ontario N6A 4G5, Canada;5. Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati 45267, OH, USA;6. Institute of Cardiovascular Science, Soochow University, Suzhou 215008, China |
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| Abstract: | - 1.1. In the study, the effect of zinc deficiency, a natural killer (NK), and lipopolysaccharide (LPS) activated NK cell activity were investigated.
- 2.2. Rats were fed with zinc-deficient and normal diet for 3 weeks.
- 3.3. NK and LPS activated NK cell activity was 7.2 ± 1.8%/106 cells (n = 10) and 9.5 ± 4.3%/106 cells (n = 10), respectively, in the zinc deficient group. In the control group fed with normal diet, NK and LPS activated NK cell activity was 22.2 ± 3.3%/106 cells (n = 10) and 32.5 ± 3.5%/106 cells (n = 10), respectively.
- 4.4. Plasma zinc concentration was 131.7 ± 8.8 μg/dl in the zinc-deficient group and 206 ± 17.7 μg/dl in the control group.
- 5.5. The results suggest that decreased NK and LPS activated NK cell activity is associated with zinc deficiency.
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