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Role of GABAA and GABAB receptors and peripheral cholinergic mechanisms in the antinociceptive action of taurine
Affiliation:1. Pharmacology Unit, Department of Pharmacology, Pediatrics and Radiology, University Hospital Macarena, E41009 Sevilla, Spain [Fax: (34)-54-370578];2. Biostatistics Unit, Department of Health and Social Sciences, Medical School, Seville University, E41009 Sevilla, Spain [Fax: (34)-54-370578];1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China;2. Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China;1. Department of Biochemistry, Faculty of Life Sciences, A.M. University, Aligarh, U.P. 202002, India;2. Department of Chemistry, Faculty of Science, A.M. University, Aligarh, U.P. 202002, India;3. Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India;1. Department of Biophysics, Faculty of Medicine, Akdeniz University, Antalya, Turkey;2. Department of Biophysics, Faculty of Medicine, Atatürk University, Erzurum, Turkey;1. Lab of Pharmacognosy, College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea;2. Gachon Medical Research Institute, Gil Medical Center, Inchon 21565, Republic of Korea;3. Gachon Institute of Pharmaceutical Science, Gachon University, #191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Republic of Korea;4. Department of Biochemistry, College of Medicine, Gachon University, #191 Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea;1. Department of Obstetrics and Gynecology, Valme University Hospital, Seville, Spain;2. Department of Obstetrics and Gynecology and the Biostatistics Unit, Department of Preventive Medicine and Public Health, University of Seville, Seville, Spain;3. University of Seville, Seville, Spain;4. Harris Birthright Research Centre for Fetal Medicine, King''s College Hospital, London, United Kingdom
Abstract:1. Gabaergic and cholinergic mediation in the antinociceptive effect of taurine has been investigated in mice (acetic acid test) and rats (tail-flick test).2. Scopolamine sulfate and methylnitrate exhibit intrinsic antinociceptive activity and increase the effect of taurine in mice.3. Baclofen also increases the antinociceptive effect of taurine in mice.4. Anticholinergic agents and bicuculline but not CGP 35348 antagonize the effect of taurine in rats.5. These results suggest that the antinociceptive effect of taurine may be partly mediated by spinal GABAA receptors and peripheral cholinergic mechanisms.
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